Solid Complex by Utilizing Some Organic Acids

Degradation of carmoful (HCFU) in the solid state was significantly accelerated by ƒÀcyclodextrin (ƒÀ-CyD) complexation owing to the hygroscopic nature of ƒÀ-CyD. The instability of HCFU in the solid complex was found to be markedly improved by the addition of some organic acids such as citric, L-( + )-tartaric and DL-malic acids, whereas DL-aspartic acid and neutral additives such as talc, lactose, cellulose and methyl cellulose had insignificant stabilizing effects. The results indicated that organic acids having lower pKa value and higher aqueous solubility are